Orthopaedic Management of Loeys-Dietz Syndrome: A Systematic Review
Journal of the AAOS Global Research & Reviews | November 2021, Vol 5, No 11
American Academy of Orthopaedic Surgeons
Conor P. Lynch, MS | Mira Patel, MBA | Andrea H. Seeley, MD | Mark A. Seeley, MD
Overview
Historically, aortic and vascular complications have been the main focus of patient care practices and research related to Loeys-Dietz syndrome (LDS); however, a number of individuals with the condition experience bone and joint issues, including scoliosis, extreme joint flexibility, osteoporosis, osteoarthritis, clubfoot, and deformities of the chest wall and hips. As individuals with LDS live longer, fuller lives, the need to manage and treat their orthopedic conditions increases significantly.
In this review, the authors examined 13 articles that discuss the management of orthopedic issues in individuals with LDS. Of the 435 individuals described in the reviewed articles, spinal complications were the most commonly reported.
Both surgical and non-surgical methods were used to treat orthopedic issues in the individuals studied. Of those who had surgery, approximately half experienced complications and a little less than half required surgery to correct the initial procedure. Those who were treated using non-surgical methods saw varying levels of success.
Given the wide range of outcomes associated with both surgical and non-surgical treatment of orthopedic issues in individuals with LDS, the authors identified the need for more high quality research on management of these complications.
From the Department of Orthopaedic Surgery
(Mr. Lynch, Ms. Patel, Dr. M.A. Seeley) and the Department of Pediatrics (Dr. A.H. Seeley), Geisinger Medical Center, Danville, PA.
Correspondence to Mr. Lynch: Conor.Lynch570@gmail.com
Dr. M.A. Seeley or an immediate family member has received personal fees from Orthopediatrics, outside the submitted work. None of the following authors or any immediate family member has received anything of value from or has stock or stock options held in a commercial company or institution related directly or indirectly to the subject of this article: Mr. Lynch, Ms. Patel, and Dr. A.H. Seeley.
JAAOS Glob Res Rev 2021;5: e21.00087
DOI: 10.5435/JAAOSGlobal-D-21-00087
Copyright 2021 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Orthopaedic Surgeons.
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